Crohn’s, UC, PsO & PsA Treatment Medication

YES to proven safety and effectiveness

YESINTEK (ustekinumab-kfce) is an FDA-approved biosimilar that’s interchangeable with Stelara, so it works as well and  is as safe as Stelara to provide you with symptom relief.^1–3

WHAT IS A BIOSIMILAR?

A biosimilar is a biologic drug that’s highly similar to the original approved medicine. This means there are no clinically meaningful differences in safety or effectiveness between the two drugs.³

WHAT IS AN INTERCHANGEABLE BIOSIMILAR?

An interchangeable biosimilar is the FDA’s designation for a biosimilar that has additional evidence demonstrating that it can be safely substituted for the original biologic medicine at the pharmacy, with the same clinical result expected in any given patient.³

29G NEEDLE¹ Thinner needle size than Stelara

NEEDLE COVER¹
Covers the needle for your safety

NEEDLE SAFETY GUARD¹  Prevents needlestick injuries

MADE WITHOUT DRY RUBBER LATEX⁴ Reduces allergic reactions

CITRATE FREE¹  Minimizes injection site pain

YESINTEK IS INDICATED FOR THE INFLAMMATORY DISEASES BELOW¹

Select your condition below to view dosing

For adults

TO GET STARTED*
One-time intravenous (IV) infusion
TO KEEP GOING^†
Subcutaneous injection (under the skin) every 8 weeks

^*Given by your doctor in a comfortable setting. It takes at least 1 hour to receive the full dose of medicine.

^†After the one-time IV infusion, you will take YESINTEK as an injection under the skin every 8 weeks.

YESINTEK has the same dosing as Stelara. If you are switching from Stelara to YESINTEK, you do not need to repeat the one-time IV infusion and should transition at your next scheduled dose. Always check with your doctor to confirm your dose.^1,2

For adults

TO GET STARTED*
One-time intravenous (IV) infusion
TO KEEP GOING^†
Subcutaneous injection (under the skin) every 8 weeks

^*Given by your doctor in a comfortable setting. It takes at least 1 hour to receive the full dose of medicine.

^†After the one-time IV infusion, you will take YESINTEK as an injection under the skin every 8 weeks.

YESINTEK has the same dosing as Stelara. If you are switching from Stelara to YESINTEK, you do not need to repeat the one-time IV infusion and should transition at your next scheduled dose. Always check with your doctor to confirm your dose.^1,2

For adults & children 6 years and older

TO KEEP GOING*
Once every 12 weeks

^*YESINTEK should be taken as an injection under the skin at Weeks 0 and 4, then every 12 weeks after.

For adults & children 6 years and older

TO KEEP GOING*
Once every 12 weeks

^*YESINTEK should be taken as an injection under the skin at Weeks 0 and 4, then every 12 weeks after.

YES to online injection training

You’re not alone in this. We’re here to guide you through the injection process with this easy-to-follow video tutorial—so you can feel confident using YESINTEK.

You can also download the full Instructions for Use (IFU) for detailed illustrations on how to use YESINTEK.

YES to
solid savings
and support

We’ve got your back. Through My Biocon Biologics^®, you’ll gain access to helpful resources for YESINTEK and may receive assistance in out-of-pocket costs.*

*Eligibility restrictions apply. Not valid for uninsured patients or patients who are covered by a state- or federally funded healthcare program. For full terms and conditions, click here.

The answer is

Yes

Biosimilars aren’t just what we do—
they’re all we do.

Biocon Biologics is fully committed to making a meaningful difference by delivering affordable global access to high-quality biosimilars such as YESINTEK.

Learn more about us at

REFERENCES

1. YESINTEK. Prescribing information. Biocon Biologics Inc; 2024. 2. STELARA. Prescribing information. Janssen Pharmaceutical Companies; 2024. 3. US Food and Drug Administration. Biosimilars: review and approval. Last updated December 13, 2022. Accessed March 11, 2024. https://www.fda.gov/drugs/biosimilars/review-and-approval 4. Data on file. Biocon Biologics; 2024.

IMPORTANT SAFETY INFORMATION

WHAT IS YESINTEK (ustekinumab-kfce)?

YESINTEK is a prescription medicine used to treat: adults and children 6 years and older with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet light alone or with pills); adults and children 6 years and older with active psoriatic arthritis; adults with moderately to severely active Crohn’s disease; adults with moderately to severely active ulcerative colitis

IMPORTANT SAFETY INFORMATION

YESINTEK is a prescription medicine that affects your immune system. YESINTEK can increase your chance of having serious side effects including:

Serious Infections

Your healthcare provider should check you for TB before starting YESINTEK.
If your healthcare provider feels that you are at risk for TB, you may be treated with medicine for TB before you begin treatment with YESINTEK and during treatment with YESINTEK.
Your healthcare provider should watch you closely for signs and symptoms of TB while you are being treated with YESINTEK.

You should not start taking YESINTEK if you have any kind of infection unless your healthcare provider says it is okay.

Before starting YESINTEK, tell your healthcare provider if you:

think you have an infection or have symptoms of an infection such as:

fever, sweats, or chills
muscle aches
cough
shortness of breath
blood in phlegm
weight loss

warm, red, or painful skin or sores on your body
diarrhea or stomach pain
burning when you urinate or urinate more often than normal
feel very tired

are being treated for an infection or have any open cuts.
get a lot of infections or have infections that keep coming back.
have TB or have been in close contact with someone with TB.

People who have a genetic problem where the body does not make any of the proteins interleukin 12 (IL-12) and interleukin 23 (IL-23) are at a higher risk for certain serious infections. These infections can spread throughout the body and cause death. People who take YESINTEK may also be more likely to get these infections.
Cancers: YESINTEK may decrease the activity of your immune system and increase your risk for certain types of cancer. Tell your healthcare provider if you have ever had any type of cancer. Some people who are receiving ustekinumab products and have risk factors for skin cancer developed certain types of skin cancers. During your treatment with YESINTEK, tell your healthcare provider if you have any new skin growths.

Before you receive YESINTEK, tell your doctor about all of your medical conditions, including if you:

have any of the conditions or symptoms listed above for serious infections, cancers, or PRES.
ever had an allergic reaction to ustekinumab or any of its ingredients. Ask your healthcare provider if you are not sure.
have recently received or are scheduled to receive an immunization (vaccine). People who take YESINTEK should not receive live vaccines. Tell your healthcare provider if anyone in your house needs a live vaccine. The viruses used in some types of live vaccines can spread to people with a weakened immune system and can cause serious problems. You should not receive the BCG vaccine during the one year before receiving YESINTEK or one year after you stop receiving YESINTEK.
have any new or changing lesions within psoriasis areas or on normal skin.
are receiving or have received allergy shots, especially for serious allergic reactions. Allergy shots may not work as well for you during treatment with YESINTEK. YESINTEK may also increase your risk of having an allergic reaction to an allergy shot.
receive or have received phototherapy for your psoriasis.
are pregnant or plan to become pregnant. It is not known if YESINTEK can harm your unborn baby. You and your healthcare provider should decide if you will receive YESINTEK.
are breastfeeding or plan to breastfeed. YESINTEK can pass into your breast milk.
talk to your healthcare provider about the best way to feed your baby if you receive YESINTEK.

How should YESINTEK be used:

Use YESINTEK exactly as your healthcare provider tells you to. The healthcare provider will determine the right dose of YESINTEK, the amount for each injection, and how often it should be given. Be sure to keep all scheduled follow up appointments.
Adults with Crohn’s disease and ulcerative colitis will receive the first dose of YESINTEK through a vein in the arm (intravenous infusion) in a healthcare facility by a healthcare provider. It takes at least 1 hour to receive the full dose of medicine. YESINTEK will be received as an injection under the skin (subcutaneous injection) 8 weeks after the first dose of YESINTEK, as described below.
Adults and children 6 years of age and older with plaque psoriasis or psoriatic arthritis will receive YESINTEK as an injection under the skin as described below.

Injecting YESINTEK under your skin:

YESINTEK is intended for use under the guidance and supervision of your healthcare provider.
In children, it is recommended that YESINTEK be administered by a healthcare provider. If your healthcare provider decides that you or a caregiver may give your injections of YESINTEK at home, you should receive training on the right way to prepare and inject YESINTEK. Do not try to inject YESINTEK until you have been shown how to inject YESINTEK by a healthcare provider.
YESINTEK can be injected under the skin in your upper arms, buttocks, upper legs (thighs) or stomach area (abdomen).
Do not give an injection in an area of the skin that is tender, bruised, red or hard.
Use a different injection site each time you use YESINTEK.

If you inject more YESINTEK than prescribed, call your healthcare provider or Poison Help line at 1-800-222-1222 or go to the nearest emergency room right away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit https://www.fda.gov/medwatch
or call 1-800-FDA-1088.

Yes

WHAT IS A BIOSIMILAR?

WHAT IS AN INTERCHANGEABLE BIOSIMILAR?

REFERENCES

IMPORTANT SAFETY INFORMATION

WHAT IS YESINTEK (ustekinumab-kfce)?

IMPORTANT SAFETY INFORMATION

WHAT IS YESINTEK (ustekinumab-kfce)?

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INDICATIONS

INDICATIONS